Very-long-chain 3-oxoacyl-CoA reductase

BE0014905ProteinHumansHSD17B12

Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. It is acted on by 1 drug in DrugBank.

Gene name
HSD17B12
UniProtKB entry
Q53GQ0Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
312 residues · 34,324 Da
Also known as
1.1.1.330 · 17-beta-HSD 12 · 17-beta-hydroxysteroid dehydrogenase 12 · 3-ketoacyl-CoA reductase · Estradiol 17-beta-dehydrogenase 12

Resolves to

Protein
UniProtQ53GQ0UniProt nameDHB12_HUMAN
Gene
HGNCHGNC:18646NCBI Gene51144GeneCardsHSD17B12
Pharmacology
KEGGhsa:51144
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
15GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
2+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Very-long-chain 3-oxoacyl-CoA reductase, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In