Cyclic nucleotide-gated channel alpha-2
Details
- Name
- Cyclic nucleotide-gated channel alpha-2
- Kind
- protein
- Synonyms
- CNCA
- CNCA1
- CNCG2
- CNG channel alpha-2
- CNG-2
- CNG2
- OCNC1
- Olfactory cyclic nucleotide-gated channel subunit 1
- Gene Name
- CNGA2
- UniProtKB Entry
- Q16280Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0017677|Cyclic nucleotide-gated channel alpha-2 MTEKTNGVKSSPANNHNHHAPPAIKANGKDDHRTSSRPHSAADDDTSSELQRLADVDAPQ QGRSGFRRIVRLVGIIREWANKNFREEEPRPDSFLERFRGPELQTVTTQEGDGKGDKDGE DKGTKKKFELFVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDY VSDVVYIADLFIRLRTGFLEQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDI HSPEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYYAISKSI GFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIG VLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNK KTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDY ICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANI RSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLDENEVATSMEVDVQEK LGQLETNMETLYTRFGRLLAEYTGAQQKLKQRITVLETKMKQNNEDDYLSDGMNSPELAA ADEP
- Number of residues
- 664
- Molecular Weight
- 76047.505
- Theoretical pI
- Not Available
- GO Classification
- Functionscalcium channel activity / calmodulin binding / cAMP binding / cGMP binding / intracellularly cAMP-activated cation channel activity / intracellularly cGMP-activated cation channel activity / protein-containing complex bindingProcessescalcium ion transport / monoatomic cation transmembrane transport / potassium ion transport / sensory perception of smell / sodium ion transportComponentsciliary membrane / Golgi-associated vesicle membrane / intracellular cyclic nucleotide activated cation channel complex / non-motile cilium membrane / plasma membrane
- General Function
- Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants. Conducts cAMP- and cGMP-gated ion currents, with permeability for monovalent and divalent cations
- Specific Function
- calcium channel activity
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- 145-166 177-197 223-241 247-265 273-296 320-354 355-379
- Cellular Location
- Cell projection, cilium membrane
- Gene sequence
- Not Available
- Chromosome Location
- X
- Locus
- Xq28
- External Identifiers
Resource Link UniProtKB ID Q16280 UniProtKB Entry Name CNGA2_HUMAN GeneCard ID CNGA2 HGNC ID HGNC:2149 KEGG ID hsa:1260 IUPHAR/Guide To Pharmacology ID 395 NCBI Gene ID 1260 - General References
- Not Available
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Dequalinium approved, investigational yes target blocker Details