Cyclic nucleotide-gated channel alpha-2

Details

Name
Cyclic nucleotide-gated channel alpha-2
Kind
protein
Synonyms
  • CNCA
  • CNCA1
  • CNCG2
  • CNG channel alpha-2
  • CNG-2
  • CNG2
  • OCNC1
  • Olfactory cyclic nucleotide-gated channel subunit 1
Gene Name
CNGA2
UniProtKB Entry
Q16280Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0017677|Cyclic nucleotide-gated channel alpha-2
MTEKTNGVKSSPANNHNHHAPPAIKANGKDDHRTSSRPHSAADDDTSSELQRLADVDAPQ
QGRSGFRRIVRLVGIIREWANKNFREEEPRPDSFLERFRGPELQTVTTQEGDGKGDKDGE
DKGTKKKFELFVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDY
VSDVVYIADLFIRLRTGFLEQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDI
HSPEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYYAISKSI
GFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIG
VLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNK
KTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDY
ICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANI
RSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLDENEVATSMEVDVQEK
LGQLETNMETLYTRFGRLLAEYTGAQQKLKQRITVLETKMKQNNEDDYLSDGMNSPELAA
ADEP
Number of residues
664
Molecular Weight
76047.505
Theoretical pI
Not Available
GO Classification
Functions
calcium channel activity / calmodulin binding / cAMP binding / cGMP binding / intracellularly cAMP-activated cation channel activity / intracellularly cGMP-activated cation channel activity / protein-containing complex binding
Processes
calcium ion transport / monoatomic cation transmembrane transport / potassium ion transport / sensory perception of smell / sodium ion transport
Components
ciliary membrane / Golgi-associated vesicle membrane / intracellular cyclic nucleotide activated cation channel complex / non-motile cilium membrane / plasma membrane
General Function
Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants. Conducts cAMP- and cGMP-gated ion currents, with permeability for monovalent and divalent cations
Specific Function
calcium channel activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
145-166 177-197 223-241 247-265 273-296 320-354 355-379
Cellular Location
Cell projection, cilium membrane
Gene sequence
Not Available
Chromosome Location
X
Locus
Xq28
External Identifiers
ResourceLink
UniProtKB IDQ16280
UniProtKB Entry NameCNGA2_HUMAN
GeneCard IDCNGA2
HGNC IDHGNC:2149
KEGG IDhsa:1260
IUPHAR/Guide To Pharmacology ID395
NCBI Gene ID1260
General References
Not Available

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Dequaliniumapproved, investigationalyestargetblockerDetails