2-hydroxyacylsphingosine 1-beta-galactosyltransferase

BE0015078ProteinHumansUGT8

Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system (PubMed:9125199). It is acted on by 1 drug in DrugBank.

Gene name
UGT8
UniProtKB entry
Q16880Swiss-Prot
Cellular location
Membrane
Residues / weight
541 residues · 61,437 Da
Also known as
2.4.1.47 · Ceramide UDP-galactosyltransferase · Cerebroside synthase · CGT · UDP-galactose-ceramide galactosyltransferase

Resolves to

Protein
UniProtQ16880UniProt nameCGT_HUMAN
Gene
HGNCHGNC:12555NCBI Gene7368GeneCardsUGT8
Pharmacology
KEGGhsa:7368
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on 2-hydroxyacylsphingosine 1-beta-galactosyltransferase, and which indications are they being tested in?

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