Sigma intracellular receptor 2

BE0015084ProteinHumansTMEM97

Sigma-2 receptor implicated in the regulation of multiple cellular processes, including cholesterol biosynthesis and trafficking, membrane trafficking, autophagy, lipid membrane-associated protein trafficking, and stabilization of receptors at the cell surface, thereby contributing to the maintenance... It is acted on by 5 drugs in DrugBank.

Gene name
TMEM97
UniProtKB entry
Q5BJF2Swiss-Prot
Cellular location
Rough endoplasmic reticulum membrane
Residues / weight
176 residues · 20,848 Da
Also known as
MAC30 · Meningioma-associated protein 30 · S2R · Sigma-2 receptor · Sigma2 receptor

Resolves to

Protein
UniProtQ5BJF2UniProt nameSGMR2_HUMAN
Gene
HGNCHGNC:28106NCBI Gene27346GeneCardsTMEM97
Pharmacology
IUPHAR/GtoPdb2553KEGGhsa:27346
Drugs

What you can answer from here — as of September 03, 2024

5DrugsApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Sigma intracellular receptor 2, and which indications are they being tested in?

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