Fatty-acid amide hydrolase 2

BE0015331ProteinHumansFAAH2

Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these... It is acted on by 1 drug in DrugBank.

Gene name
FAAH2
UniProtKB entry
Q6GMR7Swiss-Prot
Cellular location
Membrane
Residues / weight
532 residues · 58,303 Da
Also known as
3.5.1.99 · AMDD · Amidase domain-containing protein · Anandamide amidohydrolase 2 · Oleamide hydrolase 2

Resolves to

Protein
UniProtQ6GMR7UniProt nameFAAH2_HUMAN
Gene
HGNCHGNC:26440NCBI Gene158584GeneCardsFAAH2
Pharmacology
IUPHAR/GtoPdb1401KEGGhsa:158584
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Fatty-acid amide hydrolase 2, and which indications are they being tested in?

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