Lysocardiolipin acyltransferase 1

BE0015711ProteinHumansLCLAT1

Exhibits acyl-CoA:lysocardiolipin acyltransferase (ALCAT) activity; catalyzes the reacylation of lyso-cardiolipin to cardiolipin (CL), a key step in CL remodeling (By similarity). It is acted on by 1 drug in DrugBank.

Gene name
LCLAT1
UniProtKB entry
Q6UWP7Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
414 residues · 48,920 Da
Also known as
1-acylglycerol-3-phosphate O-acyltransferase 8 · 1-AGP acyltransferase 8 · 1-AGPAT 8 · 2.3.1.- · Acyl-CoA:lysocardiolipin acyltransferase 1

Resolves to

Protein
UniProtQ6UWP7UniProt nameLCLT1_HUMAN
Gene
HGNCHGNC:26756NCBI Gene253558GeneCardsLCLAT1
Pharmacology
KEGGhsa:253558
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Lysocardiolipin acyltransferase 1, and which indications are they being tested in?

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