Membrane-bound glycerophospholipid O-acyltransferase 2

BE0015719ProteinHumansMBOAT2

Acyltransferase which catalyzes the transfer of an acyl group from an acyl-CoA to a lysophospholipid leading to the production of a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known... It is acted on by 2 drugs in DrugBank.

Gene name
MBOAT2
UniProtKB entry
Q6ZWT7Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
520 residues · 59,526 Da
Also known as
1-acylglycerophosphate O-acyltransferase MBOAT2 · 1-acylglycerophosphocholine O-acyltransferase MBOAT2 · 1-acylglycerophosphoethanolamine MBOAT2 O-acyltransferase · 2.3.1.- · LPAAT

Resolves to

Protein
UniProtQ6ZWT7UniProt nameMBOA2_HUMAN
Gene
HGNCHGNC:25193NCBI Gene129642GeneCardsMBOAT2
Pharmacology
KEGGhsa:129642
Drugs

What you can answer from here — as of June 26, 2025

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Pfam domainDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Membrane-bound glycerophospholipid O-acyltransferase 2, and which indications are they being tested in?

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