Peroxisomal N(1)-acetyl-spermine/spermidine oxidase

BE0015899ProteinHumansPAOX

Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion (PubMed:12477380). It is acted on by 2 drugs in DrugBank.

Gene name
PAOX
UniProtKB entry
Q6QHF9Swiss-Prot
Cellular location
Peroxisome
Residues / weight
511 residues · 55,513 Da
Also known as
1.5.3.13 · PAO · Polyamine oxidase

Resolves to

Protein
UniProtQ6QHF9UniProt namePAOX_HUMAN
Gene
HGNCHGNC:20837NCBI Gene196743GeneCardsPAOX
Pharmacology
KEGGhsa:196743
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Peroxisomal N(1)-acetyl-spermine/spermidine oxidase, and which indications are they being tested in?

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