Dipeptidyl peptidase 8

BE0015938ProteinHumansDPP8

Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:11012666, PubMed:12534281, PubMed:12662155, PubMed:15039077, PubMed:15664838, PubMed:20536396, PubMed:29382749). It is acted on by 1 drug in DrugBank.

Gene name
DPP8
UniProtKB entry
Q6V1X1Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
898 residues · 103,358 Da
Also known as
3.4.14.5 · Dipeptidyl peptidase IV-related protein 1 · Dipeptidyl peptidase VIII · DP8 · DPP VIII

Resolves to

Protein
UniProtQ6V1X1UniProt nameDPP8_HUMAN
Gene
HGNCHGNC:16490NCBI Gene54878GeneCardsDPP8
Pharmacology
IUPHAR/GtoPdb2356KEGGhsa:54878
Structure
PDB6EOOPDB6EOPPDB6EOS
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Dipeptidyl peptidase 8, and which indications are they being tested in?

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