Dipeptidyl peptidase 8

Details

Name

Dipeptidyl peptidase 8

Kind

protein

Synonyms

• 3.4.14.5
• Dipeptidyl peptidase IV-related protein 1
• Dipeptidyl peptidase VIII
• DP8
• DPP VIII
• DPRP-1
• DPRP1
• Prolyl dipeptidase DPP8

Gene Name

DPP8

UniProtKB Entry

Q6V1X1Swiss-Prot

Organism

Humans

NCBI Taxonomy ID

9606

Amino acid sequence

>lcl|BSEQ0058960|Dipeptidyl peptidase 8
MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQ
LKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPK
TINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLF
QAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISN
IVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILR
ILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVI
DKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVM
ERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLY
KITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYF
EGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLY
KLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGK
KYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKY
KMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAP
VTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAH
TSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI

Number of residues

898

Molecular Weight

103357.575

Theoretical pI

Not Available

GO Classification

Functions

aminopeptidase activity / dipeptidyl-peptidase activity / serine-type peptidase activity

Processes

apoptotic process / immune response / negative regulation of programmed cell death / proteolysis

Components

cytoplasm / cytosol

General Function

Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:11012666, PubMed:12534281, PubMed:12662155, PubMed:15039077, PubMed:15664838, PubMed:20536396, PubMed:29382749). Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 (PubMed:27820798, PubMed:29967349, PubMed:32796818). Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation (PubMed:33731929, PubMed:33731932, PubMed:34019797). The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP8, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition (By similarity)

Specific Function

aminopeptidase activity

Pfam Domain Function

• DPPIV_N (PF00930)
• Peptidase_S9 (PF00326)
• Dpp_8_9_N (PF19520)

Signal Regions

Not Available

Transmembrane Regions

Not Available

Cellular Location

Cytoplasm

Gene sequence

Not Available

Chromosome Location

15

Locus

15q22.31

External Identifiers

Resource	Link
UniProtKB ID	Q6V1X1
UniProtKB Entry Name	DPP8_HUMAN
GeneCard ID	DPP8
HGNC ID	HGNC:16490
PDB ID(s)	6EOO, 6EOP, 6EOS, 6EOT, 6HP8, 6QZW, 6TRW, 6TRX, 7A3G, 7A3I, 7A3J, 7A3K, 7A3L, 7AYQ, 7AYR, 7OR4, 7OZ7, 7SVM, 7SVO
KEGG ID	hsa:54878
IUPHAR/Guide To Pharmacology ID	2356
NCBI Gene ID	54878

General References

Not Available

Associated Data

Drug Relations

Drug	Drug group	Pharmacological action?	Type	Actions	Details
Talabostat	investigational	yes	target	inhibitor	Details