Palmitoleoyl-protein carboxylesterase NOTUM

BE0016036ProteinHumansNOTUM

Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. It is acted on by 1 drug in DrugBank.

Gene name
NOTUM
UniProtKB entry
Q6P988Swiss-Prot
Cellular location
Secreted
Residues / weight
496 residues · 55,699 Da
Also known as
3.1.1.98 · hNOTUM

Resolves to

Protein
UniProtQ6P988UniProt nameNOTUM_HUMAN
Gene
HGNCHGNC:27106NCBI Gene147111GeneCardsNOTUM
Pharmacology
KEGGhsa:147111
Structure
PDB4UYUPDB4UYWPDB4UYZ
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Palmitoleoyl-protein carboxylesterase NOTUM, and which indications are they being tested in?

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