Histone-arginine methyltransferase CARM1

BE0016173ProteinHumansCARM1

Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability (PubMed:12237300, PubMed:16497732, PubMed:19405910). It is acted on by 1 drug in DrugBank.

Gene name
CARM1
UniProtKB entry
Q86X55Swiss-Prot
Cellular location
Nucleus
Residues / weight
608 residues · 65,853 Da
Also known as
2.1.1.319 · Coactivator-associated arginine methyltransferase 1 · PRMT4 · Protein arginine N-methyltransferase 4

Resolves to

Protein
UniProtQ86X55UniProt nameCARM1_HUMAN
Gene
HGNCHGNC:23393NCBI Gene10498GeneCardsCARM1
Pharmacology
IUPHAR/GtoPdb1255KEGGhsa:10498
Structure
PDB2Y1WPDB2Y1XPDB4IKP
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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25GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on Histone-arginine methyltransferase CARM1, how selective are they, and which programs against it are still in active trials?

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