DNA polymerase nu

BE0016315ProteinHumansPOLN

DNA polymerase with very low fidelity that catalyzes considerable misincorporation by inserting dTTP opposite a G template, and dGTP opposite a T template (PubMed:16787914, PubMed:17118716). It is acted on by 1 drug in DrugBank.

Gene name
POLN
UniProtKB entry
Q7Z5Q5Swiss-Prot
Cellular location
Nucleus
Residues / weight
900 residues · 100,306 Da
Also known as
2.7.7.7

Resolves to

Protein
UniProtQ7Z5Q5UniProt nameDPOLN_HUMAN
Gene
HGNCHGNC:18870NCBI Gene353497GeneCardsPOLN
Pharmacology
KEGGhsa:353497
Structure
PDB4XVIPDB4XVKPDB4XVL
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
1+ReferenceStructured and connected to the statements they support
Sign in

Which approved drugs act on DNA polymerase nu, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In