Xylosyltransferase 1

BE0016339ProteinHumansXYLT1

Catalyzes the first step in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans, such as DCN. It is acted on by 1 drug in DrugBank.

Gene name
XYLT1
UniProtKB entry
Q86Y38Swiss-Prot
Cellular location
Golgi apparatus membrane
Residues / weight
959 residues · 107,568 Da
Also known as
2.4.2.26 · Peptide O-xylosyltransferase 1 · XT-I · XT1 · Xylosyltransferase I

Resolves to

Protein
UniProtQ86Y38UniProt nameXYLT1_HUMAN
Gene
HGNCHGNC:15516NCBI Gene64131GeneCardsXYLT1
Pharmacology
KEGGhsa:64131
Structure
PDB6EJ7PDB6EJ8PDB6EJ9
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on Xylosyltransferase 1, how selective are they, and which programs against it are still in active trials?

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