Acyl-coenzyme A thioesterase 1

BE0016368ProteinHumansACOT1

Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. It is acted on by 1 drug in DrugBank.

Gene name
ACOT1
UniProtKB entry
Q86TX2Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
421 residues · 46,277 Da
Also known as
3.1.2.- · Acyl-CoA thioesterase 1 · CTE-I · CTE-Ib · CTE1

Resolves to

Protein
UniProtQ86TX2UniProt nameACOT1_HUMAN
Gene
HGNCHGNC:33128NCBI Gene641371GeneCardsACOT1
Pharmacology
KEGGhsa:641371
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on Acyl-coenzyme A thioesterase 1, how selective are they, and which programs against it are still in active trials?

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