Protein mono-ADP-ribosyltransferase TIPARP

Details

Name
Protein mono-ADP-ribosyltransferase TIPARP
Kind
protein
Synonyms
  • 2.4.2.-
  • ADP-ribosyltransferase diphtheria toxin-like 14
  • ARTD14
  • PARP-7
  • PARP7
  • Poly [ADP-ribose] polymerase 7
  • TCDD-inducible poly [ADP-ribose] polymerase
Gene Name
TIPARP
UniProtKB Entry
Q7Z3E1Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0059434|Protein mono-ADP-ribosyltransferase TIPARP
MEMETTEPEPDCVVQPPSPPDDFSCQMRLSEKITPLKTCFKKKDQKRLGTGTLRSLRPIL
NTLLESGSLDGVFRSRNQSTDENSLHEPMMKKAMEINSSCPPAENNMSVLIPDRTNVGDQ
IPEAHPSTEAPERVVPIQDHSFPSETLSGTVADSTPAHFQTDLLHPVSSDVPTSPDCLDK
VIDYVPGIFQENSFTIQYILDTSDKLSTELFQDKSEEASLDLVFELVNQLQYHTHQENGI
EICMDFLQGTCIYGRDCLKHHTVLPYHWQIKRTTTQKWQSVFNDSQEHLERFYCNPENDR
MRMKYGGQEFWADLNAMNVYETTEFDQLRRLSTPPSSNVNSIYHTVWKFFCRDHFGWREY
PESVIRLIEEANSRGLKEVRFMMWNNHYILHNSFFRREIKRRPLFRSCFILLPYLQTLGG
VPTQAPPPLEATSSSQIICPDGVTSANFYPETWVYMHPSQDFIQVPVSAEDKSYRIIYNL
FHKTVPEFKYRILQILRVQNQFLWEKYKRKKEYMNRKMFGRDRIINERHLFHGTSQDVVD
GICKHNFDPRVCGKHATMFGQGSYFAKKASYSHNFSKKSSKGVHFMFLAKVLTGRYTMGS
HGMRRPPPVNPGSVTSDLYDSCVDNFFEPQIFVIFNDDQSYPYFVIQYEEVSNTVSI
Number of residues
657
Molecular Weight
76226.74
Theoretical pI
Not Available
GO Classification
Not Available
General Function
ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins (PubMed:23275542, PubMed:25043379, PubMed:30373764). Acts as a negative regulator of AHR by mediating mono-ADP-ribosylation of AHR, leading to inhibit transcription activator activity of AHR (PubMed:23275542, PubMed:30373764)
Specific Function
cis-regulatory region sequence-specific DNA binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
Not Available
Chromosome Location
3
Locus
3q25.31
External Identifiers
ResourceLink
UniProtKB IDQ7Z3E1
UniProtKB Entry NamePARPT_HUMAN
GeneCard IDTIPARP
HGNC IDHGNC:23696
KEGG IDhsa:25976
IUPHAR/Guide To Pharmacology ID3266
NCBI Gene ID25976
General References
Not Available

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
AtamparibinvestigationalyestargetinhibitorDetails