Protein mono-ADP-ribosyltransferase TIPARP

BE0016431ProteinHumansTIPARP

ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins (PubMed:23275542, PubMed:25043379, PubMed:30373764). It is acted on by 1 drug in DrugBank.

Gene name
TIPARP
UniProtKB entry
Q7Z3E1Swiss-Prot
Cellular location
Nucleus
Residues / weight
657 residues · 76,227 Da
Also known as
2.4.2.- · ADP-ribosyltransferase diphtheria toxin-like 14 · ARTD14 · PARP-7 · PARP7

Resolves to

Protein
UniProtQ7Z3E1UniProt namePARPT_HUMAN
Gene
HGNCHGNC:23696NCBI Gene25976GeneCardsTIPARP
Pharmacology
IUPHAR/GtoPdb3266KEGGhsa:25976
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Protein mono-ADP-ribosyltransferase TIPARP, and which indications are they being tested in?

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