E3 ubiquitin-protein ligase HUWE1

BE0016469ProteinHumansHUWE1

E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). It is acted on by 1 drug in DrugBank.

Gene name
HUWE1
UniProtKB entry
Q7Z6Z7Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
4,374 residues · 481,886 Da
Also known as
2.3.2.26 · ARF-binding protein 1 · ARF-BP1 · HECT-type E3 ubiquitin transferase HUWE1 · HECT, UBA and WWE domain-containing protein 1

Resolves to

Protein
UniProtQ7Z6Z7UniProt nameHUWE1_HUMAN
Gene
HGNCHGNC:30892NCBI Gene10075GeneCardsHUWE1
Pharmacology
KEGGhsa:10075
Structure
PDB2EKKPDB2MULPDB3G1N
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
6Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
1+ReferenceStructured and connected to the statements they support
Sign in

Which compounds in development act on E3 ubiquitin-protein ligase HUWE1, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In