Pulmonary surfactant-associated protein A2

BE0016550ProteinHumansSFTPA2

In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. It is acted on by 1 drug in DrugBank.

Gene name
SFTPA2
UniProtKB entry
Q8IWL1Swiss-Prot
Cellular location
Secreted
Residues / weight
248 residues · 26,169 Da
Also known as
35 kDa pulmonary surfactant-associated protein · Alveolar proteinosis protein · COLEC5 · Collectin-5 · PSAP

Resolves to

Protein
UniProtQ8IWL1UniProt nameSFPA2_HUMAN
Gene
HGNCHGNC:10799NCBI Gene729238GeneCardsSFTPA2
Pharmacology
KEGGhsa:729238
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on Pulmonary surfactant-associated protein A2, how selective are they, and which programs against it are still in active trials?

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