NAD-dependent protein deacylase sirtuin-6

BE0016679ProteinHumansSIRT6

NAD-dependent protein deacetylase, deacylase and mono-ADP-ribosyltransferase that plays an essential role in DNA damage repair, telomere maintenance, metabolic homeostasis, inflammation, tumorigenesis and aging (PubMed:18337721, PubMed:19135889, PubMed:19625767, PubMed:21362626, PubMed:21680843, PubMed:23217706, PubMed:23552949, PubMed:23653361, PubMed:24052263, PubMed:27180906, PubMed:27322069, PubMed:29555651,... It is acted on by 1 drug in DrugBank.

Gene name
SIRT6
UniProtKB entry
Q8N6T7Swiss-Prot
Cellular location
Nucleus
Residues / weight
355 residues · 39,119 Da
Also known as
2.3.1.- · hSIRT6 · NAD-dependent protein deacetylase sirtuin-6 · Protein mono-ADP-ribosyltransferase sirtuin-6 · Regulatory protein SIR2 homolog 6

Resolves to

Protein
UniProtQ8N6T7UniProt nameSIR6_HUMAN
Gene
HGNCHGNC:14934NCBI Gene51548GeneCardsSIRT6
Pharmacology
IUPHAR/GtoPdb2712KEGGhsa:51548
Structure
PDB3K35PDB3PKIPDB3PKJ
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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80GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on NAD-dependent protein deacylase sirtuin-6, and which indications are they being tested in?

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