Cyclic GMP-AMP synthase

BE0016794ProteinHumansCGAS

Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:21478870, PubMed:23258413, PubMed:23707061, PubMed:23707065, PubMed:23722159, PubMed:24077100, PubMed:24116191, PubMed:24462292, PubMed:25131990, PubMed:26300263, PubMed:29976794, PubMed:30799039, PubMed:31142647, PubMed:32814054,... It is acted on by 1 drug in DrugBank.

Gene name
CGAS
UniProtKB entry
Q8N884Swiss-Prot
Cellular location
Nucleus
Residues / weight
522 residues · 58,814 Da
Also known as
2.7.7.86 · 2'3'-cGAMP synthase · C6orf150 · cGAMP synthase · cGAS

Resolves to

Protein
UniProtQ8N884UniProt nameCGAS_HUMAN
Gene
HGNCHGNC:21367NCBI Gene115004GeneCardsCGAS
Pharmacology
IUPHAR/GtoPdb3165KEGGhsa:115004
Structure
PDB4KM5PDB4LEVPDB4LEW
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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31GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Cyclic GMP-AMP synthase, and which indications are they being tested in?

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