Endonuclease V

BE0016813ProteinHumansENDOV

Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine (PubMed:23912683, PubMed:23912718, PubMed:25195743, PubMed:27573237, PubMed:31703097). It is acted on by 1 drug in DrugBank.

Gene name
ENDOV
UniProtKB entry
Q8N8Q3Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
282 residues · 30,791 Da
Also known as
3.1.26.- · hEndoV · Inosine-specific endoribonuclease

Resolves to

Protein
UniProtQ8N8Q3UniProt nameENDOV_HUMAN
Gene
HGNCHGNC:26640NCBI Gene284131GeneCardsENDOV
Pharmacology
KEGGhsa:284131
Structure
PDB4NSPPDB6OZE
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Endonuclease V, and which indications are they being tested in?

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