Patatin-like phospholipase domain-containing protein 6

BE0016881ProteinHumansPNPLA6

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). It is acted on by 2 drugs in DrugBank.

Gene name
PNPLA6
UniProtKB entry
Q8IY17Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
1,375 residues · 150,952 Da
Also known as
3.1.1.5 · Neuropathy target esterase · NTE

Resolves to

Protein
UniProtQ8IY17UniProt namePLPL6_HUMAN
Gene
HGNCHGNC:16268NCBI Gene10908GeneCardsPNPLA6
Pharmacology
KEGGhsa:10908
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Patatin-like phospholipase domain-containing protein 6, and which indications are they being tested in?

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