Sodium-dependent lysophosphatidylcholine symporter 1

BE0016969ProteinHumansMFSD2A

Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function (PubMed:24828040, PubMed:32572202, PubMed:34135507). It is acted on by 1 drug in DrugBank.

Gene name
MFSD2A
UniProtKB entry
Q8NA29Swiss-Prot
Cellular location
Cell membrane
Residues / weight
543 residues · 60,170 Da
Also known as
HsMFSD2A · Major facilitator superfamily domain-containing protein 2A · MFSD2 · MFSD2a · NLS1

Resolves to

Protein
UniProtQ8NA29UniProt nameNLS1_HUMAN
Gene
HGNCHGNC:25897NCBI Gene84879GeneCardsMFSD2A
Pharmacology
KEGGhsa:84879
Structure
PDB7OIX
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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40GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Sodium-dependent lysophosphatidylcholine symporter 1, and which indications are they being tested in?

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