Transmembrane channel-like protein 2

BE0017488ProteinHumansTMC2

Pore-forming subunit of the mechanotransducer (MET) non-selective cation channel complex located at the tips of stereocilia of cochlear hair cells and that mediates sensory transduction in the auditory system (PubMed:11850618). It is acted on by 1 drug in DrugBank.

Gene name
TMC2
UniProtKB entry
Q8TDI7Swiss-Prot
Cellular location
Cell membrane
Residues / weight
906 residues · 102,609 Da
Also known as
C20orf145 · Transmembrane cochlear-expressed protein 2

Resolves to

Protein
UniProtQ8TDI7UniProt nameTMC2_HUMAN
Gene
HGNCHGNC:16527NCBI Gene117532GeneCardsTMC2
Pharmacology
KEGGhsa:117532
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on Transmembrane channel-like protein 2, how selective are they, and which programs against it are still in active trials?

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