Transmembrane channel-like protein 1

BE0017493ProteinHumansTMC1

Pore-forming subunit of the mechanotransducer (MET) non-selective cation channel complex located at the tips of stereocilia of cochlear hair cells and that mediates sensory transduction in the auditory system (By similarity). It is acted on by 1 drug in DrugBank.

Gene name
TMC1
UniProtKB entry
Q8TDI8Swiss-Prot
Cellular location
Cell membrane
Residues / weight
760 residues · 87,767 Da
Also known as
Transmembrane cochlear-expressed protein 1

Resolves to

Protein
UniProtQ8TDI8UniProt nameTMC1_HUMAN
Gene
HGNCHGNC:16513NCBI Gene117531GeneCardsTMC1
Pharmacology
KEGGhsa:117531
Structure
PDB8XOQ
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on Transmembrane channel-like protein 1, how selective are they, and which programs against it are still in active trials?

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