Dual specificity tyrosine-phosphorylation-regulated kinase 2

BE0017531ProteinHumansDYRK2

Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth (PubMed:11311121, PubMed:12588975, PubMed:16511445, PubMed:16611631, PubMed:17349958, PubMed:18599021, PubMed:22307329, PubMed:9748265). It is acted on by 3 drugs in DrugBank.

Gene name
DYRK2
UniProtKB entry
Q92630Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
601 residues · 66,651 Da
Also known as
2.7.12.1

Resolves to

Protein
UniProtQ92630UniProt nameDYRK2_HUMAN
Gene
HGNCHGNC:3093NCBI Gene8445GeneCardsDYRK2
Pharmacology
IUPHAR/GtoPdb2011KEGGhsa:8445
Structure
PDB3K2LPDB3KVWPDB4AZF
Drugs

What you can answer from here — as of September 03, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
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22GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Dual specificity tyrosine-phosphorylation-regulated kinase 2, and which indications are they being tested in?

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