Serine protease HTRA1

BE0017623ProteinHumansHTRA1

Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. It is acted on by 1 drug in DrugBank.

Gene name
HTRA1
UniProtKB entry
Q92743Swiss-Prot
Cellular location
Cell membrane
Residues / weight
480 residues · 51,286 Da
Also known as
3.4.21.- · High-temperature requirement A serine peptidase 1 · HTRA · L56 · PRSS11

Resolves to

Protein
UniProtQ92743UniProt nameHTRA1_HUMAN
Gene
HGNCHGNC:9476NCBI Gene5654GeneCardsHTRA1
Pharmacology
IUPHAR/GtoPdb3194KEGGhsa:5654
Structure
PDB2JOAPDB2YTWPDB3NUM
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Serine protease HTRA1, and which indications are they being tested in?

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