Alpha-2,8-sialyltransferase 8B

BE0017634ProteinHumansST8SIA2

Catalyzes the transfer of a sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid of an N-linked glycan acceptor through alpha-2,8-linkages (Probable) (PubMed:10766765, PubMed:11744634, PubMed:9054414, PubMed:9774483). It is acted on by 1 drug in DrugBank.

Gene name
ST8SIA2
UniProtKB entry
Q92186Swiss-Prot
Cellular location
Golgi apparatus membrane
Residues / weight
375 residues · 42,430 Da
Also known as
2.4.3.- · Sialyltransferase 8B · Sialyltransferase St8Sia II · Sialyltransferase X · SIAT8-B

Resolves to

Protein
UniProtQ92186UniProt nameSIA8B_HUMAN
Gene
HGNCHGNC:10870NCBI Gene8128GeneCardsST8SIA2
Pharmacology
KEGGhsa:8128
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
21GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
1+ReferenceStructured and connected to the statements they support
Sign in

Which compounds in development act on Alpha-2,8-sialyltransferase 8B, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In