CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

BE0017640ProteinHumansST8SIA4

Catalyzes the transfer of a sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid of an N-linked glycan protein acceptor through alpha-2,8-linkages (PubMed:10766765, PubMed:11279095, PubMed:28810663, PubMed:9774483). It is acted on by 1 drug in DrugBank.

Gene name
ST8SIA4
UniProtKB entry
Q92187Swiss-Prot
Cellular location
Golgi apparatus membrane
Residues / weight
359 residues · 41,295 Da
Also known as
2.4.3.- · Alpha-2,8-sialyltransferase 8D · Polysialyltransferase · Polysialyltransferase-1 · PST

Resolves to

Protein
UniProtQ92187UniProt nameSIA8D_HUMAN
Gene
HGNCHGNC:10871NCBI Gene7903GeneCardsST8SIA4
Pharmacology
KEGGhsa:7903
Structure
PDB5Y22PDB5Y3UPDB6AHZ
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase, and which indications are they being tested in?

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