Piezo-type mechanosensitive ion channel component 1

BE0017696ProteinHumansPIEZO1

Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain (PubMed:23479567, PubMed:23695678, PubMed:25955826, PubMed:37590348). It is acted on by 2 drugs in DrugBank.

Gene name
PIEZO1
UniProtKB entry
Q92508Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
2,521 residues · 286,787 Da
Also known as
FAM38A · KIAA0233 · Membrane protein induced by beta-amyloid treatment · Mib · Protein FAM38A

Resolves to

Protein
UniProtQ92508UniProt namePIEZ1_HUMAN
Gene
HGNCHGNC:28993NCBI Gene9780GeneCardsPIEZO1
Pharmacology
IUPHAR/GtoPdb2945KEGGhsa:9780
Structure
PDB8YEZPDB8YFCPDB8YFG
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Piezo-type mechanosensitive ion channel component 1, how selective are they, and which programs against it are still in active trials?

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