Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

BE0018277ProteinHumansLINGO1

Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors (PubMed:14966521, PubMed:15694321). It is acted on by 1 drug in DrugBank.

Gene name
LINGO1
UniProtKB entry
Q96FE5Swiss-Prot
Cellular location
Cell membrane
Residues / weight
620 residues · 69,875 Da
Also known as
LERN1 · Leucine-rich repeat and immunoglobulin domain-containing protein 1 · Leucine-rich repeat neuronal protein 1 · Leucine-rich repeat neuronal protein 6A · LRRN6A

Resolves to

Protein
UniProtQ96FE5UniProt nameLIGO1_HUMAN
Gene
HGNCHGNC:21205NCBI Gene84894GeneCardsLINGO1
Pharmacology
IUPHAR/GtoPdb2882KEGGhsa:84894
Structure
PDB2ID5PDB4OQT
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1, and which indications are they being tested in?

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