E3 ubiquitin-protein ligase UHRF1

BE0018559ProteinHumansUHRF1

E3 ubiquitin-protein ligase that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification (PubMed:10646863, PubMed:15009091, PubMed:19056828, PubMed:23022729, PubMed:24013172, PubMed:27595565, PubMed:30104358, PubMed:30392929, PubMed:30392931, PubMed:39607687). It is acted on by 1 drug in DrugBank.

Gene name
UHRF1
UniProtKB entry
Q96T88Swiss-Prot
Cellular location
Nucleus
Residues / weight
793 residues · 89,813 Da
Also known as
2.3.2.27 · hNp95 · hUHRF1 · HuNp95 · ICBP90

Resolves to

Protein
UniProtQ96T88UniProt nameUHRF1_HUMAN
Gene
HGNCHGNC:12556NCBI Gene29128GeneCardsUHRF1
Pharmacology
KEGGhsa:29128
Structure
PDB2FAZPDB2L3RPDB2LGG
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
1GO termFunction, process and component, as structured annotations
Sign in
4Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
1+ReferenceStructured and connected to the statements they support
Sign in

Which compounds in development act on E3 ubiquitin-protein ligase UHRF1, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In