Protein phosphatase EYA3

BE0018721ProteinHumansEYA3

Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to... It is acted on by 1 drug in DrugBank.

Gene name
EYA3
UniProtKB entry
Q99504Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
573 residues · 62,662 Da
Also known as
3.1.3.48 · Eyes absent homolog 3

Resolves to

Protein
UniProtQ99504UniProt nameEYA3_HUMAN
Gene
HGNCHGNC:3521NCBI Gene2140GeneCardsEYA3
Pharmacology
KEGGhsa:2140
Structure
PDB9C7TPDB9N0Y
Drugs

What you can answer from here — as of February 11, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Protein phosphatase EYA3, and which indications are they being tested in?

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