Transcriptional enhancer factor TEF-5

BE0018748ProteinHumansTEAD3

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. It is acted on by 1 drug in DrugBank.

Gene name
TEAD3
UniProtKB entry
Q99594Swiss-Prot
Cellular location
Nucleus
Residues / weight
435 residues · 48,676 Da
Also known as
DTEF-1 · TEA domain family member 3 · TEAD-3 · TEAD5 · TEF5

Resolves to

Protein
UniProtQ99594UniProt nameTEAD3_HUMAN
Gene
HGNCHGNC:11716NCBI Gene7005GeneCardsTEAD3
Pharmacology
IUPHAR/GtoPdb3242KEGGhsa:7005
Structure
PDB5EMWPDB7CNLPDB7ZJQ
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Transcriptional enhancer factor TEF-5, and which indications are they being tested in?

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