Dehydrogenase/reductase SDR family member 9

BE0018870ProteinHumansDHRS9

3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone (PubMed:11294878, PubMed:29541409). It is acted on by 1 drug in DrugBank.

Gene name
DHRS9
UniProtKB entry
Q9BPW9Swiss-Prot
Cellular location
Microsome membrane
Residues / weight
319 residues · 35,227 Da
Also known as
1.1.1.209 · 1.1.1.53 · 3-alpha hydroxysteroid dehydrogenase · 3-alpha-HSD · NADP-dependent retinol dehydrogenase/reductase

Resolves to

Protein
UniProtQ9BPW9UniProt nameDHRS9_HUMAN
Gene
HGNCHGNC:16888NCBI Gene10170GeneCardsDHRS9
Pharmacology
KEGGhsa:10170
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Dehydrogenase/reductase SDR family member 9, and which indications are they being tested in?

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