Deoxyhypusine hydroxylase

BE0018877ProteinHumansDOHH

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. It is acted on by 1 drug in DrugBank.

Gene name
DOHH
UniProtKB entry
Q9BU89Swiss-Prot
Residues / weight
302 residues · 32,904 Da
Also known as
1.14.99.29 · Deoxyhypusine dioxygenase · Deoxyhypusine monooxygenase · hDOHH · HEAT-like repeat-containing protein 1

Resolves to

Protein
UniProtQ9BU89UniProt nameDOHH_HUMAN
Gene
HGNCHGNC:28662NCBI Gene83475GeneCardsDOHH
Pharmacology
KEGGhsa:83475
Structure
PDB4D4ZPDB4D50
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Pfam domainDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Deoxyhypusine hydroxylase, how selective are they, and which programs against it are still in active trials?

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