Target of rapamycin complex 2 subunit MAPKAP1

BE0018900ProteinHumansMAPKAP1

Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15467718, PubMed:16919458, PubMed:16962653, PubMed:17043309, PubMed:21806543, PubMed:28264193, PubMed:28968999, PubMed:30837283,... It is acted on by 4 drugs in DrugBank.

Gene name
MAPKAP1
UniProtKB entry
Q9BPZ7Swiss-Prot
Cellular location
Cell membrane
Residues / weight
522 residues · 59,122 Da
Also known as
MIP1 · Mitogen-activated protein kinase 2-associated protein 1 · mSIN1 · SAPK-interacting protein 1 · SIN1

Resolves to

Protein
UniProtQ9BPZ7UniProt nameSIN1_HUMAN
Gene
HGNCHGNC:18752NCBI Gene79109GeneCardsMAPKAP1
Pharmacology
KEGGhsa:79109
Structure
PDB3VOQPDB5ZCSPDB6ZWM
Drugs

What you can answer from here — as of September 03, 2024

4DrugsApproved to experimental, with action, bond type and pharmacological action
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30GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Target of rapamycin complex 2 subunit MAPKAP1, and which indications are they being tested in?

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