Splicing factor 3B subunit 5

BE0018936ProteinHumansSF3B5

Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:28781166, PubMed:32494006, PubMed:34822310). It is acted on by 1 drug in DrugBank.

Gene name
SF3B5
UniProtKB entry
Q9BWJ5Swiss-Prot
Cellular location
Nucleus
Residues / weight
86 residues · 10,135 Da
Also known as
Pre-mRNA-splicing factor SF3b 10 kDa subunit · SF3B10 · SF3b5

Resolves to

Protein
UniProtQ9BWJ5UniProt nameSF3B5_HUMAN
Gene
HGNCHGNC:21083NCBI Gene83443GeneCardsSF3B5
Pharmacology
KEGGhsa:83443
Structure
PDB5IFEPDB5O9ZPDB5Z56
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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22GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Splicing factor 3B subunit 5, and which indications are they being tested in?

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