Poly(A) polymerase gamma

BE0018981ProteinHumansPAPOLG

Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. It is acted on by 1 drug in DrugBank.

Gene name
PAPOLG
UniProtKB entry
Q9BWT3Swiss-Prot
Cellular location
Nucleus
Residues / weight
736 residues · 82,802 Da
Also known as
2.7.7.19 · Neo-PAP · Neo-poly(A) polymerase · PAP-gamma · PAP2

Resolves to

Protein
UniProtQ9BWT3UniProt namePAPOG_HUMAN
Gene
HGNCHGNC:14982NCBI Gene64895GeneCardsPAPOLG
Pharmacology
KEGGhsa:64895
Structure
PDB4LT6
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Poly(A) polymerase gamma, and which indications are they being tested in?

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