Queuine tRNA-ribosyltransferase catalytic subunit 1

BE0019156ProteinHumansQTRT1

Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr),... It is acted on by 1 drug in DrugBank.

Gene name
QTRT1
UniProtKB entry
Q9BXR0Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
403 residues · 44,047 Da
Also known as
2.4.2.64 · Guanine insertion enzyme · TGT · TGUT · tRNA-guanine transglycosylase

Resolves to

Protein
UniProtQ9BXR0UniProt nameTGT_HUMAN
Gene
HGNCHGNC:23797NCBI Gene81890GeneCardsQTRT1
Pharmacology
KEGGhsa:81890
Structure
PDB6H42PDB6H45PDB7NQ4
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Queuine tRNA-ribosyltransferase catalytic subunit 1, and which indications are they being tested in?

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