Pantothenate kinase 2, mitochondrial

BE0019249ProteinHumansPANK2

Mitochondrial isoform that catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis (PubMed:15659606, PubMed:16272150, PubMed:17242360, PubMed:17825826). It is acted on by 1 drug in DrugBank.

Gene name
PANK2
UniProtKB entry
Q9BZ23Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
570 residues · 62,680 Da
Also known as
2.7.1.33 · C20orf48 · hPanK2 · Pantothenic acid kinase 2

Resolves to

Protein
UniProtQ9BZ23UniProt namePANK2_HUMAN
Gene
HGNCHGNC:15894NCBI Gene80025GeneCardsPANK2
Pharmacology
KEGGhsa:80025
Structure
PDB5E26
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Pantothenate kinase 2, mitochondrial, and which indications are they being tested in?

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