WW domain-containing transcription regulator protein 1

BE0019451ProteinHumansWWTR1

Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:11118213, PubMed:18227151, PubMed:23911299). It is acted on by 1 drug in DrugBank.

Gene name
WWTR1
UniProtKB entry
Q9GZV5Swiss-Prot
Cellular location
Nucleus
Residues / weight
400 residues · 44,101 Da
Also known as
TAZ · Transcriptional coactivator with PDZ-binding motif

Resolves to

Protein
UniProtQ9GZV5UniProt nameWWTR1_HUMAN
Gene
HGNCHGNC:24042NCBI Gene25937GeneCardsWWTR1
Pharmacology
KEGGhsa:25937
Structure
PDB5N5RPDB5N5TPDB5N5W
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on WW domain-containing transcription regulator protein 1, how selective are they, and which programs against it are still in active trials?

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