UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase

BE0019533ProteinHumansDPAGT1

UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. It is acted on by 1 drug in DrugBank.

Gene name
DPAGT1
UniProtKB entry
Q9H3H5Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
408 residues · 46,089 Da
Also known as
2.7.8.15 · DPAGT2 · G1PT · GlcNAc-1-P transferase · GPT

Resolves to

Protein
UniProtQ9H3H5UniProt nameGPT_HUMAN
Gene
HGNCHGNC:2995NCBI Gene1798GeneCardsDPAGT1
Pharmacology
KEGGhsa:1798
Structure
PDB5LEVPDB5O5EPDB6BW5
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, and which indications are they being tested in?

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