Otoferlin

BE0019718ProteinHumansOTOF

Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. It is acted on by 1 drug in DrugBank.

Gene name
OTOF
UniProtKB entry
Q9HC10Swiss-Prot
Cellular location
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Residues / weight
1,997 residues · 226,751 Da
Also known as
Fer-1-like protein 2 · FER1L2

Resolves to

Protein
UniProtQ9HC10UniProt nameOTOF_HUMAN
Gene
HGNCHGNC:8515NCBI Gene9381GeneCardsOTOF
Pharmacology
KEGGhsa:9381
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on Otoferlin, how selective are they, and which programs against it are still in active trials?

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