Ribitol 5-phosphate transferase FKRP

BE0019722ProteinHumansFKRP

Catalyzes the transfer of a ribitol 5-phosphate from CDP-L-ribitol to the ribitol 5-phosphate previously attached by FKTN/fukutin to the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:26923585, PubMed:27194101, PubMed:29477842, PubMed:31949166). It is acted on by 1 drug in DrugBank.

Gene name
FKRP
UniProtKB entry
Q9H9S5Swiss-Prot
Cellular location
Golgi apparatus membrane
Residues / weight
495 residues · 54,567 Da
Also known as
2.7.8.- · Fukutin-related protein · Ribitol-5-phosphate transferase

Resolves to

Protein
UniProtQ9H9S5UniProt nameFKRP_HUMAN
Gene
HGNCHGNC:17997NCBI Gene79147GeneCardsFKRP
Pharmacology
KEGGhsa:79147
Structure
PDB6KAJPDB6KAKPDB6KAL
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
11GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
1+ReferenceStructured and connected to the statements they support
Sign in

Which compounds in development act on Ribitol 5-phosphate transferase FKRP, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In