Ribitol 5-phosphate transferase FKRP

BE0019722ProteinHumansFKRP

Catalyzes the transfer of a ribitol 5-phosphate from CDP-L-ribitol to the ribitol 5-phosphate previously attached by FKTN/fukutin to the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:26923585, PubMed:27194101, PubMed:29477842, PubMed:31949166). It is acted on by 1 drug in DrugBank.

Gene name
FKRP
UniProtKB entry
Q9H9S5Swiss-Prot
Cellular location
Golgi apparatus membrane
Residues / weight
495 residues · 54,567 Da
Also known as
2.7.8.- · Fukutin-related protein · Ribitol-5-phosphate transferase

Resolves to

Protein
UniProtQ9H9S5UniProt nameFKRP_HUMAN
Gene
HGNCHGNC:17997NCBI Gene79147GeneCardsFKRP
Pharmacology
KEGGhsa:79147
Structure
PDB6KAJPDB6KAKPDB6KAL
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
1+ReferenceStructured and connected to the statements they support
Sign in

Which compounds in development act on Ribitol 5-phosphate transferase FKRP, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In