Phosphopantothenate--cysteine ligase

BE0019777ProteinHumansPPCS

Catalyzes the second step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine (PubMed:11923312, PubMed:12906824, PubMed:29754768). It is acted on by 1 drug in DrugBank.

Gene name
PPCS
UniProtKB entry
Q9HAB8Swiss-Prot
Residues / weight
311 residues · 34,005 Da
Also known as
6.3.2.51 · COAB · Phosphopantothenoylcysteine synthetase · PPC synthetase

Resolves to

Protein
UniProtQ9HAB8UniProt namePPCS_HUMAN
Gene
HGNCHGNC:25686NCBI Gene79717GeneCardsPPCS
Pharmacology
KEGGhsa:79717
Structure
PDB1P9OPDB7EDZ
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Phosphopantothenate--cysteine ligase, and which indications are they being tested in?

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