Sialate O-acetylesterase

BE0019865ProteinHumansSIAE

Catalyzes the removal of O-acetyl ester groups from position 9 of the free diacetylated sialate N-acetyl-9-O-acetylneuraminate (Neu5,9Ac2) in the cytosol and of the diacetylated sialate residues of sialylglycoconjugates in the lysosomes (Probable). It is acted on by 1 drug in DrugBank.

Gene name
SIAE
UniProtKB entry
Q9HAT2Swiss-Prot
Cellular location
Lysosome
Residues / weight
523 residues · 58,314 Da
Also known as
3.1.1.53 · H-Lse · SIAE · Sialic acid-specific 9-O-acetylesterase · YSG2

Resolves to

Protein
UniProtQ9HAT2UniProt nameSIAE_HUMAN
Gene
HGNCHGNC:18187NCBI Gene54414GeneCardsSIAE
Pharmacology
KEGGhsa:54414
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on Sialate O-acetylesterase, how selective are they, and which programs against it are still in active trials?

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