N-lysine methyltransferase KMT5A

BE0019990ProteinHumansKMT5A

Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins (PubMed:12086618, PubMed:12121615, PubMed:15964846, PubMed:17707234, PubMed:27338793). It is acted on by 1 drug in DrugBank.

Gene name
KMT5A
UniProtKB entry
Q9NQR1Swiss-Prot
Cellular location
Nucleus
Residues / weight
393 residues · 42,889 Da
Also known as
2.1.1.- · H4-K20-HMTase KMT5A · Histone-lysine N-methyltransferase KMT5A · Lysine N-methyltransferase 5A · Lysine-specific methylase 5A

Resolves to

Protein
UniProtQ9NQR1UniProt nameKMT5A_HUMAN
Gene
HGNCHGNC:29489NCBI Gene387893GeneCardsKMT5A
Pharmacology
IUPHAR/GtoPdb2704KEGGhsa:387893
Structure
PDB1ZKKPDB2BQZPDB3F9W
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on N-lysine methyltransferase KMT5A, and which indications are they being tested in?

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