Fibroblast growth factor 21

BE0020031ProteinHumansFGF21

Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). It is acted on by 1 drug in DrugBank.

Gene name
FGF21
UniProtKB entry
Q9NSA1Swiss-Prot
Cellular location
Secreted
Residues / weight
209 residues · 22,300 Da
Also known as
FGF-21

Resolves to

Protein
UniProtQ9NSA1UniProt nameFGF21_HUMAN
Gene
HGNCHGNC:3678NCBI Gene26291GeneCardsFGF21
Pharmacology
KEGGhsa:26291
Structure
PDB5VAQPDB6M6EPDB6M6F
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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15GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Fibroblast growth factor 21, and which indications are they being tested in?

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