Xaa-Pro aminopeptidase 1

BE0020061ProteinHumansXPNPEP1

Metalloaminopeptidase that catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro (PubMed:11106490, PubMed:18515364, PubMed:35165443). It is acted on by 1 drug in DrugBank.

Gene name
XPNPEP1
UniProtKB entry
Q9NQW7Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
623 residues · 69,917 Da
Also known as
3.4.11.9 · Aminoacylproline aminopeptidase · Cytosolic aminopeptidase P · sAmp · Soluble aminopeptidase P

Resolves to

Protein
UniProtQ9NQW7UniProt nameXPP1_HUMAN
Gene
HGNCHGNC:12822NCBI Gene7511GeneCardsXPNPEP1
Pharmacology
IUPHAR/GtoPdb1578KEGGhsa:7511
Structure
PDB3CTZ
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Xaa-Pro aminopeptidase 1, and which indications are they being tested in?

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