Ribonuclease 3

BE0020070ProteinHumansDROSHA

Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. It is acted on by 1 drug in DrugBank.

Gene name
DROSHA
UniProtKB entry
Q9NRR4Swiss-Prot
Cellular location
Nucleus
Residues / weight
1,374 residues · 159,315 Da
Also known as
3.1.26.3 · p241 · Protein Drosha · Ribonuclease III · RN3

Resolves to

Protein
UniProtQ9NRR4UniProt nameRNC_HUMAN
Gene
HGNCHGNC:17904NCBI Gene29102GeneCardsDROSHA
Pharmacology
KEGGhsa:29102
Structure
PDB2KHXPDB2NA2PDB5B16
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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21GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Ribonuclease 3, and which indications are they being tested in?

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